General overview

In general, our past and current research is focused on adult (somatic) stem cells and the regulation of their fundamental biological properties including differentiation, proliferation, and migration. We are further interested in the impact of pro- and anti-inflammatory signals on neural stem cells (ancestors of nerve and glial cells), mesenchymal stem cells (progenitor of bone, fat and cartilage tissue) and neural crest-derived cells (progenitor of e.g. pigment cells and bones within the head region).

Among others, we want to address the following questions:

  • How do inflammation and infection influence stem cell-mediated regeneration of the brain and other tissues? Are pro- and anti-inflammatory signals beneficial or harmful to adult stem cells?
  • What is the ideal stem cell type for personalised regenerative medicine?
  • It is possible to increase the regenerative potential of autologous (belonging to the given patient), tissue-resident stem cells by manipulating the inflammatory balance?
  • Can terminally differentiated Schwann cells be phenotypically reverted to neural crest stem cell-like state? Can such de-differentiation approach be used within Regenerative Medicine?
  • What are the best conditions and methods to cultivate stem cells (3D vs 2D culture, biomaterials)

For more details please visit our project-specific pages listed below.

Inflammatory Signalling Pathways in Stem Cells

Neural Crest-Derived Stem Cells

Novel Approaches to Cultivation of Adult Stem Cells

Schwann Cell Dedifferentiation