Professor of Stem Cell Biology and Regenerative Medicine, University of Reading, UK
Research Division Lead, School of Pharmacy
Industrial Placement Lead, Pharmacology programme
ERASMUS and Study Abroad Coordinator, School of Pharmacy, Reading, UK
University of Reading Staff Page: https://www.reading.ac.uk/pharmacy/about/staff/d-widera.aspx
ResearcherID: http://www.researcherid.com/rid/J-4237-2012
ORCID: http://orcid.org/0000-0003-1686-130X
Google Scholar: http://scholar.google.de/citations?user=xPxpC2kAAAAJ
Researchgate: https://www.researchgate.net/profile/Darius_Widera
LinkedIn: https://www.linkedin.com/in/dariuswidera
Publons: https://publons.com/author/441900/darius-widera#profile
E-mail: d.widera[at]reading.ac.uk
h-Factor: 32
i10 index: 63
Education and Training
09/2017 Fellowship of The Higher Education Academy (UK)
09/2016 Associate Fellowship of The Higher Education Academy (UK)
11/2012 Habilitation (German full professorial qualification) and “venia legendi” for Cell Biology at the University of Bielefeld, Faculty of Biology, Germany
Habilitation-Thesis: “Alternative sources of adult stem cells for neuronal regeneration and the role of NF-kB in endogenous neural stem cells and neurons”
07/2007 Dr. rer. nat. (PhD) in Neurobiochemistry at the Institute for Neurobiochemistry (Kaltschmidt Lab), Witten/Herdecke University, Germany. Grade: summa cum laude (with distinction)
PhD-Thesis: “Novel Role of NF-kB in neural signal transduction”
11/2004 Diploma in Biochemistry (Dipl. Biochem., MSc equiv) at the Witten/Herdecke University, Germany
Diploma Thesis at the Institute for Neurobiochemistry: “MCP-1 induces migration of adult neural stem cells”
10/2002 Intermediate diploma (BSc equiv) in Biology at the University Cologne, Germany
Positions and Employment
since 08/2023 Professor of Stem Cell Biology and Regenerative Medicine, School of Pharmacy, University of Reading, Reading, United Kingdom
2022-to date: Member of the Scientific Advisory Board of Argon Medical Ltd, Germany
02/2022-to date: External Examiner, MRes Biomedical Sciences and Translational Medicine, University of Liverpool, United Kingdom
08/2019-17/2023 Associate Professor in Stem Cell Biology and Regenerative Medicine, School of Pharmacy, University of Reading, Reading, United Kingdom
2017-2020: External Examiner, Master of Research in Stem Cell Biology and Regenerative Medicine, Faculty of Medical Sciences, University of Newcastle
02/2015-07/2019: Assistant Professor (Lecturer) in Stem Cell Biology and Regenerative Medicine, School of Pharmacy, University of Reading, Reading, United Kingdom
2016-2018: External Consultant, UPM-Kymmene Corporation, Helsinki, Finland
05/2015-24/02/2022: Visting Professor at the Stavropol State Medical University (Russia)
03/2013-31/01/2015: Adjunct Professor (Privatdozent, Principal Investigator) and Senior Research Fellow (Akademischer Oberrat), Department of Cell Biology University of Bielefeld, Bielefeld, Germany
Main research topics: TLR4-mediated signaling in neural stem cells, cellular de-differentiation/reprogramming of Schwann cells; isolation, characterization, differentiation, and transplantation of adult human and murine neural and neural crest-derived stem cells in animal models, development of novel high- / super-resolution microscopy methods for biological applications
10/2007-03/2013 Research Associate (Postdoc), University of Bielefeld, Bielefeld, Germany, Department of Cell Biology (Kaltschmidt Lab)
Main research topics: isolation and characterization of adult neural and human neural crest-derived stem cells (periodontium, hard and soft palate, respiratory mucosa); the role of NF-kB in the nervous system, cellular reprogramming
12/2006-10/2007 Research Scientist (Postdoc), Molthera GmbH, Witten, Germany, Research & Development
Main research area: adult periodontal neural crest-derived stem cells; microarray analysis of oral and periodontal microflora in patient samples
2004-2007 Graduate Student, Witten/Herdecke University, Germany, Institute for Neurobiochemistry (Kaltschmidt Lab)
Research focus: human periodontal stem cells, the role of NF-kB in adult neural stem cells, application of human periodontal stem cells in critical size defect rat model of complex regeneration
2002-2004 Working student, Miltenyi Biotec, Research & Development (Assenmacher Lab, Hupert Lab, Piechaczek Lab), Bergisch Gladbach, Germany
Main research area: isolation and trans-differentiation of adult hematopoietic stem cells, software validation for the CliniMACS system
Honors, Grants and Awards
2019 ERASMUS Staff mobility grant
2018 Research Travel Grant of the University of Reading
2017 Research Travel Grant of the University of Reading
2017 Grant (PhD Studentship), Universiti Sains Malaysia, "Anti-Senescence Effects of Mesenchymal Stem Cell-derived Extracellular Vesicles"
2016 Grant (PhD Studentship), British Heart Foundation, "Impact of Toll-like Receptor 4 (TLR4)-mediated Signalling in the Modulation of Platelet Activation, Thrombosis and Haemostasis"
2016 Research Travel Grant of the University of Reading
2015 Research Travel Grant of the University of Reading
2015 Visiting Professorship at the Stavropol State Medical University, Russian Federation
2014 Official personal invitation of the Alexander von Humboldt Foundation to chair the session Neuroscience/Medicine and to act as a member of the Organizing committee of the 9th Sino-German Frontiers of Science Symposium 2016 in China
2014 Offer of a Lecturer position in Stem Cell Biology and Regenerative Medicine, University of Reading, United Kingdom, accepted
2014 Shortlisted and invited for interviews for a Lecturership (permanent Assistant Professorship) in Stem Cell Biology and Regenerative Medicine, School of Pharmacy, University of Reading, United Kingdom (ranking: primo loco)
2014 Shortlisted and invited for interviews for the Professorship “Neuroregeneration” (W2), Medical Faculty of the Heinrich-Heine University Düsseldorf , Germany, (ranking: secundo loco)
2014 Grant of the DFG (German Research Foundation) for the project “Mechanisms of neural TLR4-signaling”
2013 Selected by the Alexander von Humboldt Foundation (as one of five outstanding German stem cell scientists) as participant to the 7th Sino-German Frontiers of Science Symposium (section Stem Cells and Reprogramming) in Kunming, China, 20-23.03.2014
2013 Grant of the University of Bielefeld (FiF/Förderung Innovativer Forschung) for the project: "Investigation of the ligand-induced oligomerization of TLR4 in neural stem cells and neural cell lines"
2011 Grant of the University of Bielefeld (FiF/Förderung Innovativer Forschung) for the project: "The role of Schwann cells as novel, multipotent neural crest-derived stem cell population"
2009 Grant of the University of Bielefeld (FiF/Förderung Innovativer Forschung) for the project: "adult neural crest-derived stem cells"
2007 Award of the Rotary Foundation for the contribution to adult stem cell research
2006 Grant of the Besthorn Foundation for the project "mathematical modeling of neural stem cell proliferation"
2005 Travel grant of the Stem Cell Spring School Regenerative Medicine, University of Rostock, Germany
Professional Activities and Memberships
- Fellow of The Higher Education Academy (UK)
- Member of The Physiological Society, UK
- Member of the German Stem Cells Network (GSCN)
- Associate Editor, Frontiers in Stem Cell Research
- Academic Editor, Stem Cells International
- Associate Editor (Biology section), De Gruyter Open (2012 - 2013)
- Member of the Editorial Board, Frontiers in Neuroscience
- Member of the Expert Panel, DEBRA International (December 2015)
- until 31.01.2015 Member of the executive steering committee of the LiMiTec Bielefeld (Light Microscopy Technology Platform, University of Bielefeld, Germany)
ad-hoc reviewer for funding bodies:
- BBSRC (United Kingdom)
- MRC (United Kingdom)
- German Academic Exchange Service (DAAD, Germany)
- The British Council (United Kingdom)
- Multiple Sclerosis Society (United Kingdom)
- National Medical Research Council (Singapore)
- The Daphne Jackson Trust (United Kingdom)
- Neurological Foundation Of New Zealand (New Zealand)
- DEBRA International (Austria)
- Anniversary Fund of the Austrian National Bank for Basic Science (Austria)
- University of Luxembourg (Luxembourg)
and for the journals:
- Stem Cells
- Biomaterials
- FEBS letters
- Stem Cells and Development
- Theranostics
- Stroke
- Cell Biology International
- Molecular and Cellular Endocrinology
- Stem Cell Research and Therapy
- Neuropharmacology
- Journal of Immunology Research
- Langmuir
- European Cells and Materials
- Frontiers in Neuroscience
- Sensors and Actuators B: Chemical
- Experimental Cell Research
- International Journal of Developmental Neuroscience
Invited talks
Natural, Synthetic, and Hybrid 3D Scaffolds for Expansion and Differentiation of Adult Stem Cells
Oxford Global 3D cell culture symposium
2nd December 2021, virtual conference
Scaling up from 2D monolayers to 3D cell culture and its impact on the regenerative potential of stem cells
Cell UK series 2021
29th October 2021, London, UK
Streamlining stem cell manufacture (expert panel discussion)
Cell UK series 2021
28th October 2021, London, UK
Natural 3D scaffolds for cultivation of adult stem cells and generation of clinically compliant stem cell secretome fractions
Spring Meeting of the European Material Research Society
3rd May 2021, virtual conference
Natural and synthetic 3D cell culture systems and their impact on stem cell expansion, differentiation, and anti-inflammatory potential
CSI seminar series, INSERM U1059
26th November 2019, Saint-Etienne, France
Translational 3D cell culture systems, inflammation, and stem cell-derived extracellular vesicles
4th Congress on Regenerative Medicine
20-23rd November 2019, Lomonosov University, Moscow, Russia
Clinically Compliant, Stem Cell-Derived Biologicals in Adult Tissue Regeneration
6th Annual Stem Cell & Regenerative Medicine Congress
29-30 October 2019, London, United Kingdom
Natural and synthetic 3D cell culture systems and their impact on stem cell expansion, differentiation and anti-inflammatory potential
4th Annual Visions for 3D Cell Culture Conference
19th September 2019, Biomedicum, University of Helsinki, Finland
3D Cell Culture Systems for General Cell Culture, Clinically Compliant Expansion of Stem Cells and Isolation of Stem Cell-Derived Extracellular Vesicles
Department of Life Sciences, Brunel University London
20th July 2019, London, United Kingdom
Signalling via TLR4 in the nervous system: Taking a Toll on neuroinflammation
Max Planck Institute for Chemistry
30th January 2019, Mainz, Germany
Imaging and Analysis of Three-Dimensional Stem Cell Cultures
4th Annual Visions for 3D Cell Culture Conference
13th November 2018, Helsinki, Finland
3D Cell Culture Systems for Clinically Compliant Expansion of Adult Human Stem Cells
Stem Cell and Cancer Symposium 2018 (SSCS2018), University of Malaya
17th October 2018, Kuala Lumpur, Malaysia
Impact of Pro-inflammatory signalling on Cancer Stem Cells
Stem Cell and Cancer Symposium 2018 (SSCS2018), University of Malaya
18th October 2018, Kuala Lumpur, Malaysia
Extracellular Vesicles Derived From Neural Crest-derived Stem Cells as a Novel Approach to Stimulate Alveolar Bone Regeneration
96th General Session & Exhibition of the IADR, IADR Pan European Congress
26th July, ExCel, London, United Kingdom
3D Cell Culture Systems for Clinically Compliant Expansion of Stem Cells and Isolation of Stem Cell-Derived Extracellular Vesicles
Linked in Regeneration Lecture Series organized by the Berlin-Brandenburg School for Regenerative Therapies
1st March 2018, Charité, Berlin, Germany
Going 3D: Expansion, Differentiation and of migration of Adult Human Stem Cells in 3D Cell Culture Systems
Seminar Series of the Department of Chemical Engineering and Biotechnology, University of Cambridge
9th February 2018, Cambridge, United Kingdom
Neural Crest-Derived Stem Cells in Regenerative Medicine (keynote lecture)
3rd National Congress on Regenerative Medicine
15-18th November 2017, Moscow, Russia
3D cultivation of adult human stem cells in natural and synthetic scaffolds
3rd Annual Visions for 3D Cell Culture Seminar
13th October 2017, UPM Biofore House, Helsinki, Finland
Stem Cell-derived Extracellular Vesicles: a Novel Inflammation-targeted Approach to Treating Neurodegenerative Disorders
Seminar `Clinical and Pre-Clinical Methods for the Study of Neurodegenerative Disorders”, Instituto per la Sicurezza Sociale, Dipartimento Ospedaliero
18th September 2017, Republic San Marino
A Novel Cell-based Screening System for Investigation of Neuroinflammation
Recent Developments in Pharmaceutical Analysis 2017 (RDPA)
20-23rd September 2017, Rimini, Italy
Regenerative Properties of Extracellular Vesicles Released by Human Neural Crest-derived Stem Cells
6th MTERMS and 2nd Malaysian Stem Cell Meeting
18th November 2016, Penang, Malaysia
Adult Human Neural Crest-Derived Stem Cells Contribute to Brain Regeneration through Engraftment and Differentiation & Secretion of Anti-inflammatory Extracellular Vesicles
Institute for Science and Technology in Medicine Seminar Series, Keele University
4th November 2016, Keele, United Kingdom
Inflammatory Licencing Increases Anti-inflammatory and Immunomodulatory Potential of Stem Cell-Derived Extracellular Vesicles
UoRM Research Seminar Series
16th October 2016, Johor Bahru, EduCity@Iskandar, Malaysia
Osteogenic Potential of Neural Crest-Derived Stem Cells (online talk)
Bilateral workshop on Regenerative Medicine
14th October 2016, Tomsk, Russian Federation
Going 3D: animal-serum free cultivation method for adult human neural crest-derived stem cells
2nd Annual Visions for 3D Cell Culture Seminar
6th October 2016, UPM Biofore House, Helsinki, Finland
Adult Neural Crest-Derived Stem Cells
Seminar Series of the Department of Bioelectronics
Ecole Nationale Supérieure des Mines de Saint Etienne
Campus Georges Charpak - Provence
6th September 2016, Gardanne, France
Biased Signalling via TLR4 in Neural Cells
Single Molecule Biophysics Seminar
July 11th 2016, Goethe University Frankfurt, Frankfurt aM , Germany
Neural Crest-Derived Stem Cells and their Impact on Endogenous Regeneration
Seminar Series Stem Cell Research, Institute for Transfusion Medicine
June 30th 2016, University Duisburg-Essen, Essen, Germany
Regenerative Potential of Neural Crest-Derived Stem Cells
The Defence Science and Technology Laboratory (Dstl), Porton Down
April 6th 2016, Salisbury, United Kingdom
At the Border of Multipotency: Adult Neural Crest-Derived Stem Cells
Institute of Biomedical and Clinical Science Seminar Series
March 16th 2016, University of Exeter, Exeter, United Kingdom
Therapeutic Potential of Human Neural Crest-Derived Stem Cells
Clinical Applications of Stem Cells Meeting
February 24th 2016, Singapore
Cellular Alchemy: Converting Adult Human Stem Cells into Nerve Cells
UoRM Research Seminar Series
February 22nd 2016, Johor Bahru, EduCity@Iskandar, Malaysia
Efficacy of human stem cells to treat acute nerve injury and neurodegeneration
CONFERÊNCIA FAPESC PROEVENTOS
September 22nd, 2015, Florianópolis, Brazil
Neural crest-derived stem cells as a promising tool in regenerative neurology (Keynote talk)
Newton Researcher Links Workshop “Understanding and Advancing Therapies for CNS Disorders”
September 18th, 2015, Florianópolis, Brazil
Advanced Stem Cell Technologies
Workshop at the Stavropol State Medical University
May 15th 2015, Stavropol, Russian Federation
Neural Crest Derived Stem Cells in Regenerative Medicine (Keynote talk)
2nd International Symposium “Age of Regenerative Medicine”
May 14th, 2015, Stavropol, Russian Federation
Inflammatory Programming of Adult Stem Cells
Molecular and Cellular Medicine Research Seminars of the School of Biological Sciences
April 1st, 2015, University of Reading, Reading, United Kingdom
Human Neural Crest-Derived Stem Cells as an Alternative for Regenerative Medicine (online talk)
1st Symposium of International Concilium Medicum “Age of Regenerative Medicine”
November 11th, 2014, Stavropol, Russian Federation
Plasticity of Adult Schwann Cells Reprogrammed Towards Multipotent Neural Crest Stem Cell Phenotype (flash talk)
7th Sino-German Frontiers of Science Symposium organised by the Humboldt Foundation and The Chinese Academy of Science (CAS), Section Stem Cells and Reprogramming
March 21st, 2014, Kunming, China
Highly efficient neuronal differentiation of human inferior turbinate stem cells
Annual Conference of the GMB study group “Molecular Neurobiology”
September 15th, 2012, Bochum, Germany
Isolation and cultivation of human neural crest-derived stem cells for cell-based therapies
Biotechnica Convention, Life Science Spotlight, October 12th, 2011, Hannover, Germany
The role of NF-kappaB in adult neural and neural crest stem cells
3rd Molecular Cell Dynamics Meeting, May 6th, 2009, Münster, Germany
Human periodontium-derived neural crest stem cells: chance or risk?
4th International Meeting of the Stem Cell Network North Rhine Westphalia
October 9th, 2007, Düsseldorf, Germany
Inflammation and adult neural stem cells
Stem Cell Spring Meeting, University of Rostock
June 3rd, 2005. Rostock, Germany
Professor Darius Widera, PhD
Principal Investigator
Personal Information and CV
Professor of Stem Cell Biology and Regenerative Medicine
Research Division Lead (Pharmacy)
Industrial Placement Lead (Pharmacology)
Study Abroad Coordinator (Pharmacy & Pharmacology)
Scientific Advisory Board Member, Argon Medical Ltd
Associate Editor, Frontiers in Cell and Developmental Biology
Academic Editor, Stem Cells International
University of Reading, Whiteknights Campus
Hopkins building
Room 108
Tel: +44 (0) 118 378 7053
d.widera[at]reading.ac.uk
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Dr Kathryn Cox, PhD UoR, Whiteknights campus |
Dr Ruihan Zhou UoR, Whiteknights campus |
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Atiyeh Asadpour UoR, Whiteknights campus |
Daniel Holmes UoR, Whiteknights campus |
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Prachi Powar UoR, Whiteknights campus |
Hanh Tran UoR, Whiteknights campus |
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Nagihan Ozsoy UoR, Whiteknights campus |
Kalyani Bindu Karunakaran This email address is being protected from spambots. You need JavaScript enabled to view it. |
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Vani Pulijala UoR, Whiteknights campus |
Evangelos Akrivopoulos UoR, Whiteknights campus
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Megan Childs UoR, Whiteknights campus |
Kanniz Husain UoR, Whiteknights campus
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Alumni
Dr Yiming Mend, PhD student
Dr Jonathan Sheard, PDRA
Dr Wouter Eilers, PDRA
Dr Rocío Martínez Aguilar, visiting PhD student
Dr Donata Iandolo, Marie-Curie Fellow
Dr Mesude Bicer, PhD student
Dr Thomas Vallance, PhD student
Alessia Frigo, ERASMUS MSc student
Dr Kahdr Alatawi, PhD student
Ellie McGuire, MSc student
Enrico Carmelo Torre, ERASMUS MSc student
Dr Norodzzaida binti Ridzuan, visiting PhD student
Dr Marie Zeuner, PhD student
Hazel Robinson, MPharm student
Dexter Fernandes, MPharm student
Joanne Ossai, MPharm student, 2018
Ioannis Azoidis, MD, MRes student, 2017
Joel Metcalfe, MRes student, 2017
Dhiraj Sharma, MPharm student, 2017
Andrea Kyeremateng, MPharm student, 2017
Hajah Ishak, MPharm student, 2017
Ndidi Aliago, MPharm student, 2017
Kathryn Cottingham, MRes student
Liam Michael Turner, MRes student
Nguyen Nhat Anh Hoang, MPharm summer student
Thomas Fitzgerald, MPharm student
Sofiat Hameed, MPharm student
Grant Mehrjou, MPharm student
Katharina Volk, MSc student, 2014, University of Bielefeld, Germany
Matthias Bolowski, MSc student (external MSc thesis at the European Neuroscience Institute, Göttingen, Germany), 2014
Ines Schlotböller, BSc student, 2014, University of Bielefeld, Germany
Frederique Wieters, BSc student, 2013, University of Bielefeld, Germany
Jennifer Chudzienski, BSc student, 2013, University of Bielefeld, Germany
Simon Andre Grewe, internship student, 2013, University of Bielefeld, Germany
Ina Martin, MSc student, 2012, University of Bielefeld, Germany
The Duy Nguyen, MSc student, 2012, University of Bielefeld, Germany
Vivien Krell, student employee, 2012, University of Bielefeld, Germany
2022
Effects of 3D cell culture on the cell fate of mesenchymal stromal cells
Darius Widera
In: Haider KH. (ed) Handbook of Stem Cells. Springer. in press
Genome-Nanosurface Interaction of Titania Nanotube Arrays: Evaluation of Telomere, Telomerase and NF-κB activities on Epithelial Cell Model
Rabiatul Basria Mydin, Srimala Sreekantan, Darius Widera, Khairul Arifah Saharudin, Roshasnorlyza Hazan, and Mustafa Fadzil Farid Wajidi
RSC Adv., 2022,12, 2237-2245. doi: 10.1039/D1RA05325F
Extracellular RNAs as Outside Regulators of Gene Expression in Homeostasis and Pathology
Tatiana Lopatina, Darius Widera, and Anastasia Efimenko
Front Cell Dev Biol. 2022 Jan 6;9:818430. doi: 10.3389/fcell.2021.818430.
2021
Spiperone Stimulates Regeneration in Pulmonary Endothelium Damaged by Cigarette Smoke and Lipopolysaccharide
Evgenii G. Skurikhin, Olga Pershina, Mariia Zhukova, Darius Widera, Edgar Pan, Angelina Pakhomova, Natalia Ermakova, Victoria Skurikhina, Lubov Sandrikina, Sergey Morozov, Aslan Kubatiev, and Alexander Dygai
Int J Chron Obstruct Pulmon Dis. 2021 Dec 30;16:3575-3591. doi: 10.2147/COPD.S336410. eCollection 2021.
Potential of Stem Cells and CART as a Potential Polytherapy for Small Cell Lung Cancer
Evgenii Skurikhin, Olga Pershina, Mariia Zhukova, Darius Widera, Natalia Ermakova, Edgar Pan, Angelina V Pakhomova, Sergey Morozov, Aslan Kubatiev, and Alexander Dygai
Front Cell Dev Biol. 2021 Dec 3;9:778020. doi: 10.3389/fcell.2021.778020. eCollection 2021.
Recent Advances in Translational Adipose-Derived Stem Cell Biology
Darius Widera
Biomolecules 2021, 11(11), 1660. doi.org/10.3390/biom11111660
1,8-cineole affects agonists-induced platelet activation, thrombus formation and haemostasis
Kahdr A. Alatawi, Divyashree Ravishankar, Pabitra H. Patra, Alexander P. Bye, Alexander R. Stainer, Ketan Patel, Darius Widera, and Sakthivel Vaiyapuri
Cells, 2021 Oct 1;10(10):2616. doi: 10.3390/cells10102616.
Biophysics is reshaping our perception of the epigenome: from DNA-level to high-throughput studies
Austė Kanapeckaitė, Neringa Burokienė, Asta Mažeikienė, Graeme S. Cottrell, and Darius Widera
Biophysical Reports 2021 Dec 8; 1(2):1-23. doi: 10.1016/j.bpr.2021.100028.
TLR2 and TLR4-mediated inflammation in Alzheimer`s disease: self-defense or sabotage?
Mark L. Dallas*, and Darius Widera*
Neural Regen Res 2021;16:1552-3. *corresponding authors
Time-dependent reduction of calcium oscillations in adipose-derived stem cells differentiating towards adipogenic and osteogenic lineage
Enrico C. Torre, Mesude Bicer, Graeme S. Cottrell, Darius Widera*, and Francesco Tamagnini*
Biomolecules, 2021 Sep 23;11(10):1400. doi: 10.3390/biom11101400. *corresponding authors
Cancer Stem Cells and Somatic Stem Cells as Potential New Drug Targets, Prognosis Markers, and Therapy Efficacy Predictors in Breast Cancer Treatment
Olga Pershina, Natalia Ermakova, Angelina Pakhomova, Darius Widera, Edgar Pan, Mariia Zhukova, Elena Slonimskaya, Sergey Morozov, Aslan Kubatiev, Alexander Dygai, and Evgenii G. Skurikhin
Biomedicines. 2021 Sep 14;9(9):1223. doi: 10.3390/biomedicines9091223.
Micellar Hyaluronidase and Spiperone as a Potential Treatment for Pulmonary Fibrosis
Evgenii Skurikhin, Pavel Madonov, Olga Pershina, Natalia Ermakova, Angelina Pakhomova, Darius Widera, Edgar Pan, Mariia Zhukova, Lubov Sandrikina, Andrey Artamonov, and Alexander Dygai
Int J Mol Sci. 2021 May 25;22(11):5599. doi: 10.3390/ijms22115599.
Extracellular Vesicles from Stem and Progenitor Cells for Cell-Free Regenerative Therapy
Nazmul Haque, Darius Widera, Vijayendran Govindasamy, Pratiwi Soesilawati, and Noor Hayaty Abu Kasim
Curr Mol Med. 2021 Jan 24. doi: 10.2174/1566524021666210125114828. Online ahead of print.
Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Ameliorate Airway Inflammation in a Rat Model of chronic obstructive pulmonary disease (COPD)
Noridzzaida Ridzuan, Norashikin Zakaria, Darius Widera, Jonathan Sheard, Mitsuru Morimoto, Hirofumi Kiyokawa, Seoparjoo Azmel Mohd Isa, Gurjeet Kaur Chatar Singh, Kong-Yong Then, Ghee-Chien Ooi, and Badrul Hisham Yahaya
Stem Cell Res Ther. 2021 Jan 12;12(1):54. doi: 10.1186/s13287-020-02088-6.
Impact of 3D cell culture on bone regeneration potential of mesenchymal stromal cells
Mesude Bicer, Graeme S. Cottrell, and Darius Widera*
Stem Cell Res Ther. 2021 Jan 7;12(1):31. doi: 10.1186/s13287-020-02094-8. *corresponding author
Development and characterisation of a novel, megakaryocyte NF-κB reporter cell line for investigating inflammatory responses
Thomas M. Vallance, Jonathan J. Sheard, Yiming Meng, Enrico C. Torre, Ketan Patel, Darius Widera*, and Sakthivel Vaiyapuri*
J Thromb Haemost. 2021 Jan;19(1):107-120. doi: 10.1111/jth.15118. *corresponding authors
A muscle growth promoting treatment based on the attenuation of Activin/Myostatin signalling in young mice results in long-term testicular abnormalities
Danielle Vaughan, Robert Mitchell, Oliver Kretz, David Chambers, Maciej Lalowski, Helge Amthor, Olli Ritvos, Arja Pasternack, Antonios Matsakas, Sakthivel Vaiyapuri, Tobias B. Huber, Bernd Denecke, Abir Mukherjee, Darius Widera, and Ketan Patel
Disease Models & Mechanisms 2021 : dmm.047555 doi: 10.1242/dmm.047555
2020
Electrical Stimulation of Adipose-Derived Stem Cells in 3D Nanofibrillar Cellulose Increases Their Osteogenic Potential
Mesude Bicer, Jonathan Sheard, Donata Iandolo, Samuel Y. Boateng, Graeme S. Cottrell, and Darius Widera*
Biomolecules 2020, 10(12), 1696; doi.org/10.3390/biom10121696. *corresponding author
Antifibrotic and Regenerative Effects of Treamid in Pulmonary Fibrosis
Evgenii Skurikhin, Vladimir Nebolsin, Darius Widera, Natalia Ermakova, Olga Pershina, Angelina Pakhomova, Vyacheslav Krupin, Edgar Pan, Mariia Zhukova, Fedor Novikov, Lubov Sandrikina, Sergey Morozov, Aslan Kubatiev, and Alexander Dygai
Int J Mol Sci. 2020 Nov 8;21(21):8380. doi: 10.3390/ijms21218380.
Bisamide Derivative of Dicarboxylic Acid Contributes to Restoration of Testicular Tissue Function and Influences Spermatogonial Stem Cells in Metabolic Disorders
Angelina Pakhomova, Olga Pershina, Vladimir Nebolsin, Natalia Ermakova, Vyacheslav Krupin, Lubov Sandrikina, Edgar Pan, Darius Widera, Alexander Dygai, and Evgenii Skurikhin
Front Cell Dev Biol. 2020 Dec 3;8:562358. doi: 10.3389/fcell.2020.562358
Enhanced anti-inflammatory potential of degradation resistant curcumin/ferulic acid eutectics embedded in triglyceride-based microemulsions
Farah Sanduk, Yiming Meng, Darius Widera, Radoslaw M. Kowalczyk, Nicholas Michael Amanpreet Kaur, Vivian Yip, Sandra Zulu, Irene Zavrou, Lulu Hana, Muhammad Yaqoob, and Hisham Al-Obaidi
J Drug Deliv Sci Technol. 2020. 102067: doi.org/10.1016/j.jddst.2020.102067.
Chemical modification of pro-inflammatory proteins by peroxynitrite increases activation of TLR4 and NF-κB: Implications for the health effects of air pollution and oxidative stress
Anna Theresa Kunert, Kira Ziegler, Kathrin Reinmuth-Selzle, Anna Lena Leifke, Darius Widera, Michael Weller, Detlef Schuppan, Janine Fröhlich, Kurt Lucas, and Ulrich Pöschl.
Redox Biol. 2020 Jul 20:101581. doi: 10.1016/j.redox.2020.101581. Online ahead of print.
Inhibition of Activin/Myostatin signalling induces skeletal muscle hypertrophy but impairs mouse testicular development
Danielle Vaughan, Olli Ritvos, Robert Mitchell, Oliver Kretz, Maciej Lalowski, Helge Amthor, David Chambers, Antonios Matsakas, Arja Pasternack, Henry Collins-Hooper, Randy Ballesteros, Tobias B. Huber, Bernd Denecke, Darius Widera, Abir Mukherjee, and Ketan Patel
Eur J Transl Myol. 2020 Apr 1;30(1):8737.
Antidiabetic Effects of Bisamide Derivative of Dicarboxylic Acid in Metabolic Disorders
Angelina Vladimirovna Pakhomova, Vladimir Evgenievich Nebolsin, Olga Victorovna Pershina, Vyacheslav Andreevich Krupin, Lubov Alexandrovna Sandrikina, Edgar Sergeevich Pan, Natalia Nicolaevna Ermakova, Olga Evgenevna Vaizova, Darius Widera, Wolf-Dieter Grimm, Viacheslav Yur’evich Kravtsov, Sergey Alexandrovich Afanasiev, Sergey Georgievich Morozov, Aslan Amirkhanovich Kubatiev, Alexander Mikhaylovich Dygai, and Evgenii Germanovich Skurikhin
Int. J. Mol. Sci. 2020, 21, 991; doi:10.3390/ijms21030991
Autism: stem cell clinics are offering treatments despite lack of evidence it works (non peer-reviewed lay audience article)
Darius Widera
The Conversation UK, 21/01/2020
Single-molecule imaging reveals the oligomeric state of functional TNFα-induced plasma membrane TNFR1 clusters in cells
Christos Karathanasis, Juliane Medler, Franziska Fricke, Sonja Smith, Sebastian Malkusch, Darius Widera, Simone Fulda, Harald Wajant, Sjoerd J. L. van Wijk, Ivan Dikic, and Mike Heilemann
Science Signal. 2020 Jan 14;13(614). pii: eaax5647.
Biomimetic and electroactive 3D scaffolds for human neural crest-derived stem cell expansion and osteogenic differentiation
Donata Iandolo, Jonathan Sheard, Galit Katarivas Levy, Charalampos Pitsalidis, Ellasia Tan, Anthony Dennis, Ji-Seon Kim, Athina E. Markaki, Darius Widera, Rόisín M. Owens
MRS Communications, 1-9. doi:10.1557/mrc.2020.10
2019
Effect of ultrapure lipopolysaccharides derived from diverse bacterial species on the modulation of platelet activation
Thomas M. Vallance, Divyashree Ravishankar, Dina A. I. Albadawi, Harry Layfield, Jonathan Sheard, Rajendran Vaiyapuri, Philip Dash, Ketan Patel, Darius Widera, and Sakthivel Vaiyapuri
Sci Rep. 2019 Dec 3;9(1):18258
Optically Transparent Anionic Nanofibrillar Cellulose is Cytocompatible with Human Adipose Tissue-Derived Stem Cells and Allows Simple Imaging in 3D
Jonathan Sheard, Mesude Bicer, Yiming Meng, Alessia Frigo, Rocio Martinez Aguilar, Thomas Vallance, Donata Iandolo and Darius Widera*
Stem Cells Int, Oct 7;2019:3106929 *corresponding author
Large expert-curated database for benchmarking document similarity detection in biomedical literature search
Peter Brown, Darius Widera (as a member of the RELISH Consortium), and Yaoqi Zhou
Database: The Journal of Biological Databases and Curation. 2019 Oct 29; 1-66
Gender Differences in the Pharmacological Actions of Pegylated Glucagon-Like Peptide-1 on Endothelial Progenitor Cells and Angiogenic Precursor Cells in a Combination of Metabolic Disorders and Lung Emphysema
Olga Pershina,Angelina Pakhomova, Darius Widera, Natalia Ermakova, Anton Epanchintsev, Edgar Pan, Vyacheslav Krupin, Olga Vaizova, Olesia Putrova, Lubov Sandrikina, Irina Kurochkina, Sergey Morozov, Aslan Kubatiev, Alexander Dygai, and Evgenii Skurikhin
Int J Mol Sci. 2019 Oct 30;20(21). pii: E5414
Secretome of Mesenchymal Stem Cells and its Impact on Chronic Obstructive Pulmonary Disease
Noridzzaida Ridzuan, Darius Widera and Badrul Hisham Yahaya
In: Pham P. (ed) Stem Cell Transplantation for Autoimmune Diseases and Inflammation.
Stem Cells in Clinical Applications. Springer, Cham. 2019. 139-157
Investigating in vitro amyloid peptide 1-42 aggregation: impact of higher molecular weight stable adducts
Angela De Simone, Marina Naldi, Daniele Tedesco, Andrea Milelli, Manuela Bartolini, Lara Davani, Darius Widera, Mark L. Dallas and Vincenza Andrisano
ACS Omega. 2019 Jul 19 ;4(7):12308-12318.
Secretome of Adipose-Derived Mesenchymal Stem Cells Promotes Skeletal Muscle Regeneration through Synergistic Action of Extracellular Vesicle Cargo and Soluble Proteins
Robert Mitchell, Ben Mellows, Jonathan Sheard, Manuela Antonioli, Oliver Kretz, David Chambers, Marie-Theres Zeuner, James E Tomkins, Bernd Denecke, Luca Musante, Barbara Joch, Florence Debacq-Chainiaux, Harry Holthofer, Steve Ray, Tobias B Huber, Joern Dengjel, Paolo De Coppi, Darius Widera* and Ketan Patel*
Stem Cell Res Ther. 2019 Apr 5;10(1):116. doi: 10.1186/s13287-019-1213-1. * corresponding authors
TLR4 and PAR2 in physiology and pathophysiology of the nervous system: more than just receptor cooperation?
Darius Widera*, Rocío Martínez Aguilar and Graeme S. Cottrell
Neural Regen Res. 2019 Jul;14(7):1196-1201. doi: 10.4103/1673-5374.251290. *corresponding author
Stem Cells from Human Extracted Deciduous Teeth Expanded in Foetal Bovine and Human Sera Express Different Paracrine Factors after Exposure to Freshly Prepared Human Serum
Nazmul Haque, Darius Widera and Noor Hayaty Abu Kasim
Adv Exp Med Biol. 2019 Feb 16. doi: 10.1007/5584_2018_299. [Epub ahead of print]
Tissue Repair and Regenerative Mechanisms by Stem/Progenitor Cells and Their Secretome (Editorial)
Roberto Gramignoli , Fabio Sallustio, Darius Widera and Nathanael Raschzok
Front Med (Lausanne). 2019 Jan 31;6:11. doi: 10.3389/fmed.2019.00011. eCollection 2019
2018
From fibroblasts to medicinal signalling cells: a paradigm shift in translational stem cell research
Jonathan Sheard, Thamil Selvee Ramasamy and Darius Widera*
Drug Target Review, 2018 May 31;2018(2): 42-44. *corresponding author
Inhibition of NF-κB signalling reduces the stemness characteristics of lung cancer stem cells
Norashikin Zakaria, Narazah Mohd Yusoff, Zubaidah Zakaria, Darius Widera and Badrul H. Yahaya
Front Oncol. 2018 May 17;8:166
Isolation and Characterisation of Neural Crest-Derived Stem Cells from Adult Ovine Palatal Tissue
Marie-Theres Zeuner, Nikolai N. Didenko, David Humphries, Sokratis Stergiadis, Taryn Morash, Ketan Patel, Wolf-Dieter Grimm and Darius Widera*
Front Cell Dev Biol. 2018 Apr 11;6:39. doi: 10.3389/fcell.2018.00039. eCollection 2018. *corresponding author
2017
Quantitative single-molecule imaging of TLR4 reveals ligand-specific receptor dimerization
Carmen L. Krüger, Marie-Theres Zeuner, Graeme S. Cottrell, Darius Widera and Mike Heilemann
Science Signal. 2017 Oct 31;10(503). pii: eaan1308. doi: 10.1126/scisignal.aan1308.
Toll-like Receptor 4 Signalling and its Impact on Platelet Function, Thrombosis, and Haemostasis
Thomas Vallance, Marie-Theres Zeuner, Harry F. Williams, Darius Widera* and Sakthivel Vaiyapuri*
Mediators Inflamm. 2017;2017:9605894. doi 10.1155/2017/9605894. 
*corresponding authors
3D Cell Culture of Human Mesenchymal Stem Cells in Nanofibrillar Cellulose Hydrogels
Ioannis Azoidis, Joel Metcalfe, James Reynolds, Shirley Keeton, Sema Hakki, Jonathan Sheard and Darius Widera*
MRS Communications. 2017 Aug 11, doi:10.1557/mrc.2017.59. [Epub ahead of print], *corresponding author
Protein and molecular characterisation of a clinically compliant amniotic fluid stem cell derived extracellular vesicle fraction capable of accelerating muscle regeneration through the enhancement of angiogenesis
Ben Mellows, Robert Mitchell, Manuela Antonioli, Oliver Kretz, David Chambers, Marie-Theres Zeuner, Bernd Denecke, Luca Musante, Durrgah Ramachandra, Florence Debacq-Chainiaux, Harry Holthofer, Steve Ray, Darius Widera, Anna L David, Tobias B. Huber, Joern Dengjel, Paolo De Coppi and Ketan Patel
Stem Cells Dev. 2017 Jul 5. doi: 10.1089/scd.2017.0089. [Epub ahead of print]
Development and Characterisation of a Novel NF-κB Reporter Cell Line for Investigation of Neuroinflammation
Marie-Theres Zeuner, Thomas Vallance, Sakthivel Vaiyapuri, Graeme S. Cottrell and Darius Widera*
Mediators Inflamm. 2017;2017:6209865. doi: 10.1155/2017/6209865. Epub 2017 Jul 16. *corresponding author
The Use of Mesenchymal Stromal Cells in Treatment of Lung Disorders
Egi Kardia, Norashikin Zakaria, Nur Shuhaidatul Sarmiza Abdul Halim, Darius Widera and Badrul Hisham Yahaya
Regen Med. 2017 Mar;12(2):203-216. doi: 10.2217/rme-2016-0112.
2016
Biased Signalling is an Essential Feature of TLR4 in Glioma Cells
Marie-Theres Zeuner, Carmen L Krüger, Katharina Volk, Karen Bieback, Graeme S Cottrell, Mike Heilemann and Darius Widera*
Biochim Biophys Acta. 2016 Sep 23;1863(12):3084-3095. doi: 10.1016/j.bbamcr.2016.09.016, *corresponding author
Single-Particle Tracking Uncovers Dynamics of Glutamate-Induced Retrograde transport of NF-κB p65 in living neurons
Darius Widera*, Christin Klenke, Deepak Nair, Meike Heidbreder, Sebastian Malkusch, Jean-Baptiste Sibarita, Daniel Choquet, Barbara Kaltschmidt, Mike Heilemann*, Christian Kaltschmidt*
Neurophotonics. 2016 Oct;3(4):041804. doi: 10.1117/1.NPh.3.4.041804 
, *corresponding authors
1,8-cineole potentiates IRF3-mediated antiviral response in human stem cells and an ex vivo model of rhinosinusitis
Janine Müller, Johannes FW Greiner, Marie-Theres Zeuner, Viktoria Brotzmann, Johanna Schafermann, Frederique Wieters, Darius Widera, Holger Sudhoff, Barbara Kaltschmidt and Christian Kaltschmidt
Clin Sci (Lond). 2016 Aug 1;130(15):1339-52. doi: 10.1042/CS20160218.
Paracrine effects of TLR4-polarised mesenchymal stromal cells are mediated by extracellular vesicles
Marie-Theres Zeuner, Ketan Patel, Bernd Denecke, Bernd Giebel and Darius Widera*
J Transl Med. 2016 Feb 2;14(1):34. doi: 10.1186/s12967-016-0794-z. , *corresponding author
2015
Helium Ion Microscopy Visualizes Lipid Nanodomains in Mammalian Cells
Matthias Schürmann, Natalie Frese, André Beyer, Peter Heimann, Darius Widera, Viola Mönkemöller, Thomas Huser, Barbara Kaltschmidt, Christian Kaltschmidt, Armin Gölzhäuser
Small. 2015 Oct 5. doi: 10.1002/smll.201501540
Translational Research and Therapeutic Applications of Neural Crest-Derived Stem Cells in Regenerative Periodontology
Wolf-Dieter Grimm, Bernd Giesenhagen, Sema Hakki, Ingmar Schau, Sergey Sirak, Alexandr Sletov, Gabor Varga, Alexander Vukovic and Darius Widera
Current Oral Health Reports, Stem Cell Biology For Tooth And Periodontal Regeneration, 2015 Sep 23. doi: 10.1007/s40496-015-0067-6
Controversial Role of Toll-like Receptor 4 in Adult Stem Cells
Marie Zeuner, Karen Bieback and Darius Widera*
Stem Cell Rev. 2015 Aug;11(4):621-34. doi: 10.1007/s12015-015-9589-5. * corresponding author
Alternative generation of CNS neural stem cells and PNS derivatives from neural crest derived peripheral stem cells
Marlen Weber, Galina Apostolova, Darius Widera, Michel Mittelbronn, Georg Dechant, Barbara Kaltschmidt and Hermann Rohrer
Stem Cells. 2015 Feb;33(2):574-88. doi: 10.1002/stem.1880.
Intrastriatal transplantation of adult human neural crest-derived stem cells improves functional outcome in Parkinsonian rats
Janine Müller, Christiana Ossig, Johannes F.W. Greiner, Stefan Hauser, Mareike Fauser, Darius Widera, Christian Kaltschmidt, Alexander Storch and Barbara Kaltschmidt
Stem Cells Transl Med. 2015 Jan;4(1):31-43. doi: 10.5966/sctm.2014-0078.
2014
Interaction of adult human neural crest-derived stem cells with nanoporous titanium surface is sufficient to induce their osteogenic differentiation
Matthias Schürmann, Annalena Wolff, Darius Widera, Stefan Hauser, Peter Heimann, Andreas Hütten, Christian Kaltschmidt and Barbara Kaltschmidt
Stem Cell Res. 2014 May 9;13(1):98-110. doi: 10.1016/j.scr.2014.04.017. [Epub ahead of print]
Culture bag systems for clinical applications of adult human neural crest-derived stem cells
Lena-Marie Grunwald, Johannes FW Greiner, Janine Müller, Darius Widera, Christian Kaltschmidt and Barbara Kaltschmidt
Stem Cell Res Ther. 2014 Mar 14;5(2):34. [Epub ahead of print]
Quantitative single-molecule localization microscopy combined with rule-based modeling reveals ligand-induced TNF-R1 reorganization towards higher order oligomers
Franziska Fricke, Sebastian Malkusch, Gaby Wangorsch, Johannes F. Greiner, Barbara Kaltschmidt, Christian Kaltschmidt , Darius Widera, Thomas Dandekar , Mike Heilemann
Histochem Cell Biol. 2014 Feb 12. [Epub ahead of print]
Methods for Modulation and Analysis of NF-kappaB-dependent Adult Neurogenesis
Darius Widera, Yvonne Imielski, Christian Kaltschmidt and Barbara Kaltschmidt
J Vis Exp. 2014 Feb 13;(84). doi: 10.3791/50870.
An Investigation of the Specificity of Research Antibodies against NF-κB-subunit p65
Carsten Slotta, Janine Müller, Loan Tran, Stefan Hauser, Darius Widera, Barbara Kaltschmidt and Christian Kaltschmidt
J Histochem Cytochem. 2014 Feb;62(2):157-61
2013
Prolonged cultivation of hippocampal neural precursor cells shifts their differentiation potential and selects for aneuploid cells
The Duy Nguyen*, Darius Widera*, Johannes Greiner, Janine Müller, Ina Martin, Carsten Slotta, Stefan Hauser, Christian Kaltschmidt and Barbara Kaltschmidt
Biol Chem. 2013 Dec;394(12):1623-36. doi: 10.1515/hsz-2013-0191. *equal contribution
1,8-Cineol inhibits nuclear translocation of NF-κB p65 and NF-κB-dependent transcriptional activity.
Johannes F.-W. Greiner, Janine Müller, Marie-Theres Zeuner, Thorsten Seidel, Christin Zander, Stefan Hauser, Darius Widera, Holger Sudhoff, Barbara Kaltschmidt and Christian Kaltschmidt
Biochim Biophys Acta. 2013 Dec;1833(12):2866-78.
Simple method for sub-diffraction resolution imaging of cellular structures on standard confocal microscopes by three-photon absorption of quantum dots.
Anje Sporbert, Meike Heidbreder, Petra Domaing, Stefan Hauser, Zoltan Cseresnyes, Barbara Kaltschmidt, Christian Kaltschmidt, Mike Heilemann and Darius Widera*
PLoS ONE 2013 Mai 21; 8(5): e64023. doi:10.1371/journal.pone.0064023. *corresponding author
Hsc70 is a novel interactor of NF-kappaB p65 in living hippocampal neurons
Christin Klenke, Darius Widera *, Thomas Engelen, Janine Müller, Thomas Noll, Karsten Niehaus, M. Lienhard Schmitz, Barbara Kaltschmidt and Christian Kaltschmidt
PLoS One. 2013 Jun 7;8(6):e65280. doi: 10.1371/journal.pone.0065280. Print 2013. *equal contribution
Improved method for ex ovo-cultivation of developing chicken embryos for human stem cell xenografts
Timo Schomann, Firas Qunneis, Darius Widera, Christian Kaltschmidt and Barbara Kaltschmidt
Stem Cells Int, 2013,2013, http://dx.doi.org/10.1155/2013/960958
An intronic G run within HIV-1 intron 2 is critical for splicing regulation of vif mRNA
Marek Widera, Steffen Erkelenz, Frank Hillebrand, Aikaterini Krikoni, Darius Widera, Wolfgang Kaisers, René Deenen, Michael Gombert, Rafael Dellen, Tanya Pfeiffer, Barbara Kaltschmidt, Carsten Münk, Valerie Bosch, Karl Köhrer, and Heiner Schaal
J Virol. 2013 Mar;87(5):2707-20. doi: 10.1128/JVI.02755-12. Epub 2012 Dec 19.
2012
Adult Craniofacial Stem Cells: Sources and Relation to the Neural Crest
Barbara Kaltschmidt, Christian Kaltschmidt and Darius Widera *
Stem Cell Rev. 2012 Sep;8(3):658-71. *corresponding author
Book Chapter: TNF receptor membrane dynamics studied with fluorescence methods.
Felix Neugart, Darius Widera*, Barbara Kaltschmidt, Christian Kaltschmidt and Mike Heilemann*.
Fluorescent Methods to Study Biological Membranes.-Springer Series on Fluorescence, DOI:10.1007/4243_2012_60 2012, 439-457 *corresponding authors
Identification of Novel Cholesteatoma-related Gene Expression Signatures Using Full-genome Microarrays
Christin Zander, Sebastian Janowski, Daniela Borck, Darius Widera, Jörg Ebmeyer, Jörn Kalinowski, Anke Leichtle, Ralf Hofestädt, Tahwinder Upile, Christian Kaltschmidt, Barbara Kaltschmidt and Holger Sudhoff
PLoS One. 2012;7(12):e52718. doi: 10.1371/journal.pone.0052718. Epub 2012 Dec 20.
Label-free enrichment of leucozytozoids using flow cytometric cell sorting
Johannes Greiner, Nayden Chakarov, Stefan Hauser, Daniel Schützmann, Martina Boerner, Oliver Krüger and Darius Widera*
Parasitology. 2012 Oct;139(12):1547-52. doi: 10.1017/S0031182012000972. Epub 2012 Jul 19. *corresponding author
Generation of Schwann cell-derived multipotent neurospheres isolated from intact sciatic nerve
Ina Martin, The Duy Nguyen, Vivien Krell, Johannes F.W. Greiner, Janine Müller, Peter Heimann and Darius Widera*
Stem Cell Rev. 2012 Dec;8(4):1178-87. doi: 10.1007/s12015-012-9387-2. *corresponding author
Orgin and regenerative potential of vertebrate mechanoreceptor-associated stem cells
Darius Widera, Stefan Hauser, Christian Kaltschmidt and Barbara Kaltschmidt
Anatomy Research International, vol. 2012, 2012, doi:10.1155/2012/837626
TNF-a alpha influences the lateral dynamics of TNF receptor I in living cells
Meike Heidbreder, Christin Zander, Sebastian Malkusch Darius Widera, Barbara Kaltschmidt, Christian Kaltschmidt, Deepak Nair, Jean-Baptiste Sibarita, Daniel Choquet, Mike Heilemann
Biochim Biophys Acta Molecular Cell Research. 2012 Oct;1823(10):1984-9. Epub 2012 Jun 27.
Isolation of Novel Multipotent Neural Crest-Derived Stem Cells from Adult Human Inferior Turbinate
Stefan Hauser, Darius Widera, Firas Qunneis, Janine Müller, Christin Zander, Johannes Greiner, Christina Strauss, Patrick Lüningschrör, Peter Heimann, Holger Sudhoff, Marcos J. Araúzo-Bravo, Boris Greber, Holm Zaheres, Hans Schöler, Christian Kaltschmidt and Barbara Kaltschmidt
Stem Cells Dev. 2012 Mar 20;21(5):742-56. Epub 2012 Jan 26.
2011
Efficient animal-serum free 3D cultivation method for adult human neural crest-derived stem cell therapeutics
Johannes Greiner, Stefan Hauser, Darius Widera, Firas Qunneis, Janine Müller, Christin Zander, Ina Martin, Jana Mallah, Christian Prante, Hartmut Schwarze, Wolfgang Prohaska, André Beyer, Karsten Rott, Andreas Hütten, Armin Gölzhäuser, Holger Sudhoff, Christian Kaltschmidt and Barbara Kaltschmidt
Eur Cell Mater. 2011 Dec 17;22:403-19.
Schwann Cells Can Be Reprogrammed to Multipotency by Culture
Darius Widera, Peter Heimann, Christin Zander, Yvonne Imielski, Meike Heidbreder, Mike Heilemann, Christian Kaltschmidt and Barbara Kaltschmidt
Stem Cells Dev. 2011 Dec;20(12):2053-64. Epub 2011 Jun 1.
2010
Subdiffraction Fluorescence Imaging of Biomolecular Structure and Distributions with Quantum Dot Triexciton Imaging (QDTI)
Meike Heidbreder, Ulrike Endesfelder, Sebastian van de Linde, Simon Hennig, Darius Widera, Barbara Kaltschmidt, Christian Kaltschmidt and Mike Heilemann
Biochim Biophys Acta Molecular Cell Research. 2010 Oct;1803(10):1224-9. Epub 2010 Jun 23.
Morphological characterization of periodontium-derived human stem cells
Wolfgang Arnold, Sebastian Becher, Aous Dannan, Darius Widera, Thomas Dittmar, Monica Jacob, Hans Georg Mannherz, Barbara Kaltschmidt, Christian Kaltschmidt, Wolf-Dieter Grimm
Ann Anat. 2010 Aug 20;192(4):215-9. Epub 2010 Jun 11.
Neural stem cells adopt tumorigenic properties by constitutively activated NF-kappaB and subsequent VEGF up-regulation
Aljoscha Kaus*, Darius Widera*, Susannah Kassmer, Jan Peter, Kurt Zaenker, Christian Kaltschmidt and Barbara Kaltschmidt
Stem Cells Dev. 2010 Jul;19(7):999-1015,*equal contribution
2009
Adult palatum as a novel source of neural crest-related stem cells
Darius Widera *, Christin Zander*, Meike Heidbreder, Yvonne Kasperek, Thomas Noll, Oliver Seitz, Belma Saldamli, Holger Sudhoff H, Robert Sader, Christian Kaltschmidt and Barbara Kaltschmidt
Stem Cells.2009 Aug;27(8):1899-910. * equal contribution
Book Chapter: NF-kappaB, Potential Role in Adult Neural Stem Cells
Darius Widera, Christian Kaltschmidt and Barbara Kaltschmidt
In: Binder, Hirokawa, Windhorst, Hirsch (Eds.) Encyclopedia of Neuroscience. Springer Verlag, Berlin, 2009: 2862 - 2867.
2008
Neural stem cells, inflammation and NF-kappaB: basic principle of maintenance and repair or origin of brain tumours?
Darius Widera, Aljoscha Kaus, Ilja Mikenberg, Christian Kaltschmidt and Barbara Kaltschmidt
J Cell Mol Med. 2008 Mar-Apr;12(2):459-70. Epub 2007 Dec 20.
2007
Impact of polysialylated CD56 on natural killer cell cytotoxicity
Jeannette M. Moebius, Darius Widera, Jürgen Schmitz, Christian Kaltschmidt and Christoph Piechaczek
BMC Immunology, 2007 Aug 6;8(1):13
Transcription factor NF-kappaB is transported to the nucleus via cytoplasmic dynein/dynactin motor complex in hippocampal neurons
Ilja Mikenberg, Darius Widera, Aljoscha Kaus, Barbara Kaltschmidt and Christian Kaltschmidt
PLOS One, 2007 Jul 11;2:e589
Highly Efficient neural differentiation of human somatic stem cells, isolated via minimally-invasive periodontal surgery
Darius Widera, Wolf Dieter Grimm, Jeannette M. Moebius, Ilja Mikenberg, Christoph Piechaczek, Georg Gassmann, Natascha A Wolff, Frank Thévenod, Christian Kaltschmidt and Barbara Kaltschmidt
Stem Cells Dev. 2007 Jun;16(3):447-60.
2006
Mathematical model for NF-kappaB driven proliferation of adult neural stem cells
Monika Piotrowska*, Darius Widera *, Barbara Kaltschmidt, Uwe an der Heiden and Christian Kaltschmidt
Cell Prolif, 39(6):441-455. Epub 2006 Nov 15, *equal contribution
Tumor Necrosis Factor alpha triggers proliferation of adult neural stem cells via IKK/NF-kappaB signaling
Darius Widera, Ilja Mikenberg, Margitta Elvers, Christian Kaltschmidt and Barbara Kaltschmidt
BMC Neuroscience 2006 Sep 20; 7:64
Potential Role of NF-kappaB in Adult Neural Stem Cells: the Underrated Steersman?
Darius Widera, Ilja Mikenberg, Barbara Kaltschmidt and Christian Kaltschmidt
Int J Dev Neurosci. 2006 Apr-May;24(2-3):91-102. Epub 2006 Jan 18
Long-term depression activates transcription of immediate early transcription factor genes: involvement of SRF/Elk-1
Antje Lindecke, Martin Korte, Marta Zagrebelsky, Volker Horejschi, Margitta Elvers,
Darius Widera, Maria Prüllage, Julia Pfeiffer, Barbara Kaltschmidt and Christian Kaltschmidt
Eur J Neuroscience, 2006 Jul;24(2):555-63
Nuclear Factor-kappaB controls the reaggregation of 3D neurosphere cultures in vitro
Darius Widera, Ilja Mikenberg, Aljoscha Kaus, Christian Kaltschmidt and Barbara Kaltschmidt
Eur Cell Mater. 2006 May 23;11:76-85
TNF-alpha mediated transport of NF-kappaB to the nucleus is independent of the cytoskeleton-based transport system in non-neuronal cells
Ilja Mikenberg,Darius Widera, Aljoscha Kaus, Barbara Kaltschmidt and Christian Kaltschmidt
Eur J Cell Biol. 2006 Jun;85(6):529-36. Epub 2006 Apr 3
2005
Signalling via NF-kB in the nervous system
Barbara Kaltschmidt, Darius Widera and Christian Kaltschmidt
Biochim Biophys Acta. 2005 Sep 30;1745(3):287-99
Book Chapter: The role of NF-kappaB in brain function
Barbara Kaltschmidt, Ilja Mikenberg, Darius Widera and Christian Kaltschmidt
In: Thiel (Ed.) Transcription Factors in the Nervous System, Wiley-VCH, Weinheim, 2005
2004
MCP-1 induces migration of adult neural stem cells
Darius Widera, Wolf Holtkamp, Frank Entschladen, Bernd Niggemann, Kurt Zänker, Barbara Kaltschmidt, and Christian Kaltschmidt
Eur J Cell Biol. 2004 Aug;83(8):381-7
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